I can\'t believe that neither a Google or SO search has turned up a definitive answer or even much discussion for this, but:
Is it possible to edit/customize keyboar
There are key mappers for every OS which allow overriding default key combinations; here are a few:
Fork and extend the Chrome Shortcut Manager for native functionality.
References
Texter
AutoHotKey
xType
AutoKey
Chrome Shortcut Manager