Is there a reason why not to use link-time optimization (LTO)?

Question

GCC, MSVC, LLVM, and probably other toolchains have support for link-time (whole program) optimization to allow optimization of calls among compilation units.

Is the

Answer 1

If you have well written code, it should only be advantageous. You may hit a compiler/linker bug, but this goes for all types of optimisation, this is rare.

Biggest downside is it drastically increases link time.