Does creating an object using reflection rather than calling the class constructor result in any significant performance differences?
Reflection is slow, though object allocation is not as hopeless as other aspects of reflection. Achieving equivalent performance with reflection-based instantiation requires you to write your code so the jit can tell which class is being instantiated. If the identity of the class can't be determined, then the allocation code can't be inlined. Worse, escape analysis fails, and the object can't be stack-allocated. If you're lucky, the JVM's run-time profiling may come to the rescue if this code gets hot, and may determine dynamically which class predominates and may optimize for that one.
Be aware the microbenchmarks in this thread are deeply flawed, so take them with a grain of salt. The least flawed by far is Peter Lawrey's: it does warmup runs to get the methods jitted, and it (consciously) defeats escape analysis to ensure the allocations are actually occurring. Even that one has its problems, though: for example, the tremendous number of array stores can be expected to defeat caches and store buffers, so this will wind up being mostly a memory benchmark if your allocations are very fast. (Kudos to Peter on getting the conclusion right though: that the difference is "150ns" rather than "2.5x". I suspect he does this kind of thing for a living.)