I just installed Visual Studio 2017. After starting an ASP.NET MVC application I get the message that chrome debugging in Visual Studio is enabled.
But my breakpoint
I finally got all my break points to begin hitting after I right clicked on IIS Express and Exit after working for many hours.
I had debugger in my script files and break points and as soon as I did a Clean Solution > Debug my breakpoints started to begin to hit again.
I understand how frustrating this is and I am just letting the stackoverflow community know what worked for me.