Web applications frameworks such as sinatra (ruby), play (scala), lift (scala) produces a web server listening to a specific port.
I know there are some reasons like
And just in case you want the semi-official answer from Isaac Schluetter at the Airbnb tech talk on January 30, 2013 around 40 minutes in he addresses the question of whether node is stable & secure enough to serve connections directly to the Internet. His answer is essentially "yes" it is fine. So you can do it and you will probably be fine from a stability and security standpoint (assuming you are using cluster to handle unexpected termination of an app server process), but as detailed above the reality of current operations is that still almost everybody runs node behind a separate web server or reverse proxy/cache.