I want to design a URL shortener for a particular use case and type of end-user that I have targetted. I have decided that I want the URLs to be stored internally according
You need a Block Cipher with "Block Space" of 266.
Choose an arbitrary key for the cipher, and you now have a transformation that is reversible by you, yet unpredictable for everyone else.
Your block size is a bit unusual, so you probably won't find a ready-made good block cipher for your size. But as suggested by kquinn you can design one on your own that mimics other ciphers.