Using the csv module and a list comprehension:
import csv
with open('foo.csv') as f:
reader = csv.reader(f, skipinitialspace=True)
header = next(reader)
a = [dict(zip(header, map(int, row))) for row in reader]
print a
Output:
[{'col3': 3, 'col2': 2, 'col1': 1}, {'col3': 6, 'col2': 5, 'col1': 4}]