I've used partial classes to "physically" separate static data access methods from business class properties and methods in an active record architecture. For example, we had Company and CompanyData partial classes side-by-side. The advantage was that one file was the POCO and the other contained only data access methods. This was a stepping stone to removing data access to repository classes in a legacy application. I think that was a legitimate use, it certainly made the re-factoring process saner.
