I\'ve recently taken it as a project to teach myself how to program in Python. Overall, I must say that I\'m impressed with it.
In the past I\'ve typically stuck to
There is a set of cross platform Python utilities - called xlrd, xlwt, and xlutils - for reading & writing Excel files. There are some limitations (e.g. I don't think they can process macros), but they do allow you to work with Excel files on non-Windows platforms, if that's of use to you. See: http://www.python-excel.org/
Also, there are SO questions already dealing with this sort of topic, including this: Is there a better way (besides COM) to remote-control Excel?