First, I create my database.
create database mydb;
I add \"south\" to installed Apps. Then, I go to this tutorial: http://south.aeracode.
This seems obvious, but I'd highly recommend reading the docs.
Even after reading the answers to this question I struggled to understand how to use South effectively.
That all changed of course the day I read the docs and you should too, South is simpler to use than you might think.
http://south.aeracode.org/docs/about.html
http://south.aeracode.org/docs/tutorial/index.html
http://south.aeracode.org/docs/convertinganapp.html#converting-an-app
I also found this useful:
http://www.djangopro.com/2011/01/django-database-migration-tool-south-explained/
And make sure you read Jeff Atwood's Coding Horror articles on database version control.