Global.asax not firing for Release build

Question

One of our applications has a mechanism for emailing our Helpdesk automatically should it encounter a certain level of exception. One particular exception, a NullReferenceEx

Answer 1

If you need to avoid PrecompiledApp file and publish Global.asax, please go to Publish and move to setting tab at bottom and uncheck the precompile during publishing.

Belove image will be help you