I am reading a csv into a:
a
import csv import collections import pdb import math import urllib def do_work(): a=get_file(\'c:/pythonwork/cds/c
The problem is you're not doing anything with the result of replace. In Python strings are immutable so anything that manipulates a string returns a new string instead of modifying the original string.
replace
line[8] = line[8].replace(letter, "")