Instant run in Android Studio 2.0 (how to turn off)

Question

How to disable Instant Run in Android Studio 2.0 Preview. When I go to the settings I see it:

and I can not remove the tick from \"Enable Instant Run...\"

Answer 1

Update August 2019

In Android Studio 3.5 Instant Run was replaced with Apply Changes. And it works in different way: APK is not modified on the fly anymore but instead runtime instrumentation is used to redefine classes on the fly (more info). So since Android Studio 3.5 instant run settings are replaced with Deployment (Settings -> Build, Execution, Deployment -> Deployment):