Given this list
my_lst = [\'LAC\', \'HOU\', \'03/03 06:11 PM\', \'2.13\', \'1.80\', \'03/03 03:42 PM\']
I want to change its 0th
if you want something shorter, you can exploit the series function in pandas
import pandas as pd
A = ['A','B','A','C','D'] #list we want to replace with a dictionary lookup
B = {'A':1,'B':2,'C':3,'D':4} #dictionary lookup, dict values in B will be mapped to entries in A
C = (pd.Series(A)).map(B) #convert the list to a pandas series temporarily before mapping
D = list(C) # we transform the mapped values (a series object) back to a list
# entries in D = [1,2,1,3,4]