So today I decided I would update to Visual Studio 2015 (previously running the RC version with no difficulties) but now my project does not like the largeaddressaware comma
The issue was caused when uninstalling the Visual Studio 2015 RC version. It does not remove all the directories and therefore the install of the full release version is not successful. The simple solution is to uninstall the RC version and restart. Then manually delete the C:\Program Files (x86)\Microsoft Visual Studio 14.0 directory. Then you can install the the new version without any issues.
Credit Hans Passant for identifying this issue.