I have a mysql table that looks like this:
1 value1 value2 3534 2 value1 value1 8456 3 value1 value2 3566 4 value1 value3 734
Assuming that the first column is unique, you can do this:
SELECT id, col2, col3, col4 FROM yourtable WHERE id IN ( SELECT MIN(id) FROM yourtable GROUP BY col2, col3 )
See it working online: sqlfiddle