I have been having this weird problem with Xcode 4.3.2, of course after the recent update.
After successfully building and running on the simulator several times, xc
This has frustrated me for -years- now but stumbled across what appears to get things going again for me:
Hide the simulator (iOS Simulator -> Hide iOS Simulator) or Cmd-H, then reopen the simulator.
The problem seems to happen when something CPU intensive is happening in the background (like a Time Machine backup) on my old 2 core MacBook.