Exact error:
Severity Code Description Project File Line Suppression State Error DEP0001 : Unexpected Error: -1988945906 TestApp
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I faced this problem after I uninstalled Windows 10 SDK. It deleted the IpOverUsbSvc service from the system.
Download the Windows 10 SDK .iso installer
Inside it there is Installers folder.
Find Windows IP Over USB-x86_en-us.msi. Install it. (Don't worry if there is no setup window, it installs fast and silently).
I didn't even have to reboot VS2015, it just worked.
Check if the IpOverUsbSvc service is running
Get-Service -Name *USB*