I have an extension method to safe casting objects, that looks like this:
public static T SafeCastAs(this object obj) {
if (obj == null)
You use whatever you have the information for.
If you have an instance and a static type you want to check against, use is.
If you don't have the static type, you just have a Type object, but you have an instance you want to check, use IsInstanceOfType.
If you don't have an instance and you just want to check the compatibility between a theoretical instance of a Type and another Type, use IsAssignableFrom.
But really is seems like you are just re-implementing the as operator (except that yours would also work for non-nullable value types, which is usually not a big limitation).