I would suggest taking a look at the profiler in Firebug, and the Drip plugin for IE to help look for memory leaks.
Also, just keep in mind that most javascript memory leaks come from circular references between DOM objects and javascript objects not being broken when the DOM object is unloaded. To prevent that, I would suggest avoiding creating references to javascript objects in DOM object properties (ie, avoid something like document.getElementById('foo').bar = myObject;). If you must create these circular references, be sure to break them yourself in a function that runs when the page unloads, or when removing the DOM objects prior to unload.
