PEP 08 states:
Imports are always put at the top of the file, just after any module comments and docstrings, and before module globals and constants.<
Module initialization only occurs once - on the first import. If the module in question is from the standard library, then you will likely import it from other modules in your program as well. For a module as prevalent as datetime, it is also likely a dependency for a slew of other standard libraries. The import statement would cost very little then since the module intialization would have happened already. All it is doing at this point is binding the existing module object to the local scope.
Couple that information with the argument for readability and I would say that it is best to have the import statement at module scope.