Do whatever you want to do after the file loads successfully.just after the completion of your file processing set the value of file control to blank string.so the .change() will always be called even the file name changes or not. like for example you can do this thing and worked for me like charm
$('#myFile').change(function () {
LoadFile("myFile");//function to do processing of file.
$('#myFile').val('');// set the value to empty of myfile control.
});