As a reminder it is not good practice to place clustered indices on random surrogate keys i.e. GUIDs that read XY8D7-DFD8S, as they SQL Server has no ability to physically sort these data. You should instead place unique indices on these data, though it may be also beneficial to simply run SQL profiler for the main table operations and then place those data into the Database Engine Tuning Advisor.
See thread @ http://social.msdn.microsoft.com/Forums/en-us/sqlgetstarted/thread/27bd9c77-ec31-44f1-ab7f-bd2cb13129be
