I was thinking about the classic issue of lazy singleton initialization - the whole matter of the inefficiency of:
if (instance == null)
{
instance = new
the whole matter of the inefficiency of:...
What inefficiency?
Those instructions will result into an extremely fast fragments of assembly code. I am completely sure that there is nothing to be gained by trying to "optimize" this. Even if you come up with something faster, it will be at a significant complexity cost.
Unless you do have positive evidence that this code is affecting your performance, you should use the simplest approach that solves your problem.