If you are relying on an implementation of Python that has a Global Interpreter Lock (i.e. CPython) and writing multithreaded code, do you really need locks at all?
No - the GIL just protects python internals from multiple threads altering their state. This is a very low-level of locking, sufficient only to keep python's own structures in a consistent state. It doesn't cover the application level locking you'll need to do to cover thread safety in your own code.
The essence of locking is to ensure that a particular block of code is only executed by one thread. The GIL enforces this for blocks the size of a single bytecode, but usually you want the lock to span a larger block of code than this.