I have a Vim autocmd that removes trailing whitespace in files before write. I want this almost 100% of the time, but there are a few filetypes that I\'d like it disabled. C
*.rb isn't a filetype. It's a file pattern. ruby is the filetype and could even be set on files that don't have a .rb extension. So, what you most likely want is a function that your autocmd calls to both check for filetypes which shouldn't be acted on and strips the whitespace.
fun! StripTrailingWhitespace()
" Don't strip on these filetypes
if &ft =~ 'ruby\|javascript\|perl'
return
endif
%s/\s\+$//e
endfun
autocmd BufWritePre * call StripTrailingWhitespace()
Building on evan's answer, you could check for a buffer-local variable and determine whether to do the strip using that. This would also allow you to do one-off disabling if you decided that you don't want to strip a buffer that's a filetype you normally would strip.
fun! StripTrailingWhitespace()
" Only strip if the b:noStripeWhitespace variable isn't set
if exists('b:noStripWhitespace')
return
endif
%s/\s\+$//e
endfun
autocmd BufWritePre * call StripTrailingWhitespace()
autocmd FileType ruby,javascript,perl let b:noStripWhitespace=1