I\'ve pretty much tried every Python web framework that exists, and it took me a long time to realize there wasn\'t a silver bullet framework, each had its own advantages an
Have you taken a look at CherryPy. It is minimalistic, yet efficient and simple. It is low level enough for not it to get in they way, but high enough to hide complexity. If I remember well, TurboGears was built on it.
With CherryPy, you have the choice of much everything. (Template framework, ORM if wanted, back-end, etc.)