So I am using Win7 x64 with VS2010 and have installed the IE10 Win7 Preview and ReSharper 6.1.
When I attempt to Start Debugging, I receive the following:
I have had the same problem since updating to IE 10 on a Win 7 Pro machine running VS 2010 SP1.
I tried numerous suggestions, but none worked. I finally fixed it by downgrading to IE 9, to wit:
Debugging works again.