So I am using Win7 x64 with VS2010 and have installed the IE10 Win7 Preview and ReSharper 6.1.
When I attempt to Start Debugging, I receive the following:
I was having the same problem with VS2010 & IE10 (Win7). After weeks of trying to resolve this issue I finally decided to fire up VS2012 to debug my site. I also updated VS2012 to SP1 and restarted my machine and now VS2010 debugging works fine in IE10.
So try installing VS2012 SP1 to fix compatibility issues with VS2010 & IE10.