See the abc module. Basically, you define __metaclass__ = abc.ABCMeta on the class, then decorate each abstract method with @abc.abstractmethod. Classes derived from this class cannot then be instantiated unless all abstract methods have been overridden.
If your class is already using a metaclass, derive it from ABCMeta rather than type and you can continue to use your own metaclass.
A cheap alternative (and the best practice before the abc module was introduced) would be to have all your abstract methods just raise an exception (NotImplementedError is a good one) so that classes derived from it would have to override that method to be useful.
However, the abc solution is better because it keeps such classes from being instantiated at all (i.e., it "fails faster"), and also because you can provide a default or base implementation of each method that can be reached using the super() function in derived classes.
