Python List Indexing Efficiency

Question

Quick question about the built in python list object. Say you have a list with the numbers 0 - 99. You are writing a program that takes the last item in the list and uses

Answer 1

Why not test and see?

import timeit
t=timeit.timeit('mylist[99]',setup='mylist=list(range(100))',number=10000000)
print (t)
t=timeit.timeit('mylist[-1]',setup='mylist=list(range(100))',number=10000000)
print (t)

Of course, as you can see by running this a couple times, there's really no (noticable) difference for the reasons pointed out in the other answers.