Is a GUID unique 100% of the time?
Will it stay unique over multiple threads?
If your system clock is set properly and hasn't wrapped around, and if your NIC has its own MAC (i.e. you haven't set a custom MAC) and your NIC vendor has not been recycling MACs (which they are not supposed to do but which has been known to occur), and if your system's GUID generation function is properly implemented, then your system will never generate duplicate GUIDs.
If everyone on earth who is generating GUIDs follows those rules then your GUIDs will be globally unique.
In practice, the number of people who break the rules is low, and their GUIDs are unlikely to "escape". Conflicts are statistically improbable.