I\'m installing python on my windows 10 laptop, and when I try to run it I get this.
Fatal Python error: Py_Initialize: unable to load the file system
I had the same problem (I use a mac but I don't think it makes any difference in this problem) and it was coming from the difference between the selected python interpreter path and the current working directory in spyder.
I use virtual environments in python to avoid version conflicts of installed modules between various projects (I believe it is a good practice). This leads me ton configure the interpreter path in spyder by accessing :
preferences > python interpreter > use the following interpreter
The problem comes when I launch spyder from a different path. I get exactly the same error as Milo's. To solve it I see 2 options :