I am working on a project which requires some pretty intricate JavaScript processing. This includes a lot of nested if-elses in quite a few places.
Maybe slightly, but I don't think it will be measurable unless the rest of the function involves "heavy" (and otherwise redundant since I assume that a return would give same result) js calls.
As a side note, I think this is unnecessary micro optimization, and you should probably look elsewhere for performance improvements, ie profile the script through Chrome's developer tools or Firebug for Firefox (or similar tools) and look for slow/long running calls/functions.