I have a puzzle site and its an awful way of cheating. Its okay if only partially, but can it be done?
Something I had in mind was replacing the letters with images, but
I would presume that using keydown would enable this, however as a matter of principle, changing the way that a browser behaves is a bad idea. Although it is more of a pain for you to do, there are font replacement techniques that should make it easier.
If you do find a means of doing this, there is always a danger that someone will get around it. It is far better to write the page to work whatever than hack the browser.