body, html {
display: table;
height: 100%;
width: 100%;
}
.container {
display: table-cell;
vertical-align: middle;
}
.container .box {
width: 100px;
height: 100px;
background: red;
margin: 0 auto;
}
http://jsfiddle.net/NPV2E/
"width:100%" for the "body" tag is only for an example. In a real project you may remove this property.