I use Firebug and the Mozilla JS console heavily, but every now and then I run into an IE-only JavaScript bug, which is really hard to locate (ex: error on line 724
This is the free version of Debug Bar but I find it easier to use and have the features I need. Great to test little JavaScript snippets in IE the same way I do with Firebug in Firefox.
EDIT 5 years later: I now uses Internet Explorer integrated developer tools.