Difference of two date time in sql server

Question

Is there any way to take the difference between two datetime in sql server?

For example, my dates are

1. 2010-01-22 15:29:55.090

Answer 1

SELECT DATEDIFF (MyUnits, '2010-01-22 15:29:55.090', '2010-01-22 15:30:09.153')

Substitute "MyUnits" based on DATEDIFF on MSDN