Please explain what are the main differences and when should I use what.
The focus on web multi-threaded applications.
Consider using ReaderWriterLock if you have lots of threads that only need to read the data and these threads are getting blocked waiting for the lock and and you don’t often need to change the data.
However ReaderWriterLock may block a thread that is waiting to write for a long time.
Therefore only use ReaderWriterLock after you have confirmed you get high contention for the lock in “real life” and you have confirmed you can’t redesign your locking design to reduce how long the lock is held for.
Also consider if you can't rather store the shared data in a database and let it take care of all the locking, as this is a lot less likely to give you a hard time tracking down bugs, iff a database is fast enough for your application.
In some cases you may also be able to use the Aps.net cache to handle shared data, and just remove the item from the cache when the data changes. The next read can put a fresh copy in the cache.
Remember
"The best kind of locking is the locking you don't need (i.e. don't share data between threads)."