Debugging TypeScript code with Visual Studio

Question

Is there a way to debug TypeScript source in Visual Studio (instead of debugging the generated javascript)?

From the TypeScript language specifications:

Answer 1

short answer: Restart Visual Studio

background: I had 2 visual studio 2015 instances with two different projects with TypeScript. The first started instance did not debug correctly, the second one did. All of the project settings were the same. I finally restarted the first instance and then it debugged TypeScript (finally).