I have a dataframe which looks like this:
A B C 1 red78 square big235 2 green circle small123 3 blue45 triangle big657
You can use .str.replace with a regex:
.str.replace
dfObject['C'] = dfObject.C.str.replace(r"[a-zA-Z]",'')
output:
A B C 1 red78 square 235 2 green circle 123 3 blue45 triangle 657