I have just updated my android SDK tools to the newly released version (tools version 22, platform tools version 17)
java.lang.NoClassDefFoundError
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I had a similar issue after the upgrade. The problem in my case was that the android-support-v4.jar library had become unchecked in the Order and Export- list. Check + rebuild solved it for me.
The error manifested itself by crashing the app when opening a dialog with a Facebook LoginButton widget on it.