All good answers, but my hot-button has been hit - performance.
If the code being run spends all its time calling library/system routines - file operations, database operations, sending windows messages, then it doesn't matter very much if it's JITted, because most of the clock time is spent waiting for those lower-level operations to complete.
However, if the code contains things we usually call "algorithms", that have to be fast and don't spend much time calling functions, and if those are used often enough to be a performance problem, then JIT is very important.
