this is so domain-specific that its hardly worth answering. use your freaking head.
- space shuttle operating system: nope, no memory leaks allowed
- rapid development proof-of-concept code: fixing all those memory leaks is a waste of time.
and there is a spectrum of intermediate situations.
the opportunity cost ($$$) of delaying a product release to fix all but the worst memory leaks is usually dwarfs any feelings of being "sloppy or unprofessional". Your boss pays you to make him money, not to get a warm, fuzzy feelings.