Sqliteman is my current preference: It uses QT, so it's cross-platform. Since I develop on Windows, Linux and OS X, it helps to have the same tools available on each.
I also tried SQLite Admin (Windows, so irrelevant to the question anyway) for a while, but it seems unmaintained these days, and has the most annoying hotkeys of any application I've ever used - Ctrl-S clears the current query, with no hope of undo.
