On a 32-bit CPU, an integer is 4 bytes and a short integer is 2 bytes. If I am writing a C/C++ application that uses many numeric values that will always fit within the pro
Yes, you should definitely use a 32 bit integer on a 32 bit CPU, otherwise it may end up masking off the unused bits (i.e., it will always do the maths in 32 bits, then convert the answer to 16 bits)
It won't do two 16 bit operations at once for you, but if you write the code yourself and you're sure it won't overflow, you can do it yourself.
Edit: I should add that it also depends somewhat on your definition of "efficient". While it will be able to do 32-bit operations more quickly, you will of course use twice as much memory.
If these are being used for intermediate calculations in an inner loop somewhere, then use 32-bit. If, however, you're reading this from disk, or even if you just have to pay for a cache miss, it may still work out better to use 16-bit integers. As with all optimizations, there's only one way to know: profile it.