Delphi: why breakpoints from time to time are not usable (green highlighted line on IDE)?

Question

From time to time I lose breakpoint functionality in Delphi.

I thought this to be a Delphi 2009 issue but now I have also it in Delphi XE.

In Delphi 2009 by

Answer 1

I had MSBuild checked under Delphi Compile (we do MS Builds). That was preventing breakpoints from working. Unchecked and it works.