Microsoft.Office.Interop.Excel.WorkbookClass.SaveAs() method is working fine on Windows server 2003 and also on XP but not on Windows server 2008. I copied it a
It 'a permission problem when IIS is running I had this problem and I solved it in this way
I went on folders
C:\Windows\ System32\config\SystemProfile
and
C:\Windows\SysWOW64\config\SystemProfile
are protected system folders, they usually have the lock.
Right-click-> Card security-> Click on Edit-> Add untente "Autenticadet User" and assign permissions.
At this point everything is solved, if you still have problems try to give all permissions to "Everyone"