Honeypots are one effective method. Phil Haack gives one good honeypot method, that could be used in principle for any forum/blog/etc.
You could also write a crawler that follows spam links and analyzes their page to see if it's a genuine link or not. The most obvious would be pages with an exact copy of your content, but you could pick out other indicators.
Moderation and blacklisting, especially with plugins like these ones for WordPress (or whatever you're using, similar software is available for most platforms), will work in a low-volume environment. If your environment is a low volume one, don't underestimate the advantage this gives you. Personally deciding what is reasonable content and what isn't gives you ultimate flexibility in spam control, if you have the time.
Don't forget, as others have pointed out, that CAPTCHAs are not limited to text recognition from an image. Visual association, math problems, and other non-subjective questions relayed through an image also qualify.
