Ned Batchelder wrote up a technique that combines hashes with honeypots for some wickedly effective bot-prevention. No captchas, just code.
It's up at Stopping spambots with hashes and honeypots:
Rather than stopping bots by having people identify themselves, we can stop the bots by making it difficult for them to make a successful post, or by having them inadvertently identify themselves as bots. This removes the burden from people, and leaves the comment form free of visible anti-spam measures.
This technique is how I prevent spambots on this site. It works. The method described here doesn't look at the content at all. It can be augmented with content-based prevention such as Akismet, but I find it works very well all by itself.
